Alpha-Ketoglutarate (AKG) for Aging: What the Research Actually Shows
TL;DR: Alpha-ketoglutarate (AKG) is a metabolite in the Krebs cycle that declines by roughly 50% between ages 40 and 70. A 2020 Cell Metabolism study…
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Berberine vs. Metformin for Longevity: What the Evidence Actually Shows
TL;DR: Berberine and metformin share a core mechanism — both activate AMPK — and both lower fasting glucose comparably in head-to-head trials. Metformin brings 70…
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Biological Age Tests Compared: Noise Alone Can Move Your Result 9 Years
TL;DR: When the same blood sample was run twice, six widely used epigenetic clocks disagreed with themselves by as much as 9 years (Higgins-Chen, Nature…
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How to Slow Immune Aging With Spermidine: The Protocol a 2026 Trial Actually Tested
TL;DR: A 2026 double-blind trial in Aging Cell found that 6mg of spermidine daily for 13 weeks reduced immune cell senescence markers, enhanced autophagy in…
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What Is the Upper Limit of Human Lifespan? A 2026 Nature Study Has the Math.
TL;DR: A 2026 mathematical modeling study in npj Aging calculated that if somatic DNA mutations were the only remaining aging mechanism, median human lifespan would…
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Can Yogurt Prevent Colon Cancer? What the Harvard Study Actually Found
TL;DR: Headlines claimed yogurt prevents colon cancer, but the 2025 Harvard-led study found something more specific: regular yogurt intake was linked to lower risk of…
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A Daily Multivitamin Slowed Cognitive Aging by 2 Years in Three Independent Trials
Key Takeaways What the COSMOS Trial Was The COcoa Supplement and Multivitamin Outcomes Study (COSMOS) was one of the largest randomized supplementation trials ever conducted….
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CoQ10 and Selenium Reduced Cardiovascular Mortality by Nearly 50% in a 10-Year Trial
Key Takeaways Why CoQ10 and Selenium Matter in Aging Coenzyme Q10 (CoQ10) has two primary jobs. First, it is a critical cofactor in the mitochondrial…
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Omega-3 Slowed Biological Aging on 3 Epigenetic Clocks in a 3-Year Trial
Key Takeaways The DO-HEALTH Trial and What It Measured The DO-HEALTH trial enrolled 2,157 generally healthy adults aged 70 and older across five European countries:…
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Dietary Nucleotides Reduced Biological Age by 3 Years in a Double-Blind Trial
Key Takeaways What Dietary Nucleotides Are Nucleotides are small molecules that form the building blocks of DNA and RNA. Every time your cells divide, every…
