Did a 4-Week Diet Reverse Biological Age? What the Sydney Trial Actually Measured
TL;DR: In a 2026 University of Sydney trial, 104 adults aged 65 to 75 ate one of four fully provided diets for 4 weeks. Three…
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Does Hyperbaric Oxygen Therapy Reverse Aging? Myth vs. Data
TL;DR: No. In the randomized trials we identified, HBOT has not been shown to reverse biological age measured with validated epigenetic clocks. The “age reversal”…
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How to Lower Biological Age: What Randomized Trials Actually Show
TL;DR: Only a handful of randomized trials have tested whether a lifestyle or supplement intervention changes DNA methylation measures of biological age. Caloric restriction (CALERIE),…
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Low-Dose Lithium for Brain Aging: The Evidence and What an Evidence-Based Protocol Looks Like
TL;DR: Texas counties with higher lithium in drinking water showed significantly lower Alzheimer’s mortality. A 2025 study found lithium levels are lower in Alzheimer’s brains….
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Rapamycin for Longevity: What the PEARL Trial Actually Found After 48 Weeks in Humans
114 adults, 48 weeks, placebo-controlled: the first rigorous human rapamycin longevity trial found a 5% lean mass gain in women and a favorable safety profile.
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Antioxidant Supplements Slow Aging: What the Science Actually Shows
The largest human trials — 296,707 participants across 78 RCTs — show antioxidant supplements increase mortality, not reduce it. Here is what the data actually says, and what works instead.
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Alpha-Ketoglutarate (AKG) for Aging: What the Research Actually Shows
TL;DR: Alpha-ketoglutarate (AKG) is a metabolite in the Krebs cycle that declines by roughly 50% between ages 40 and 70. A 2020 Cell Metabolism study…
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Berberine vs. Metformin for Longevity: What the Evidence Actually Shows
TL;DR: Berberine and metformin share a core mechanism — both activate AMPK — and both lower fasting glucose comparably in head-to-head trials. Metformin brings 70…
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Biological Age Tests Compared: Noise Alone Can Move Your Result 9 Years
TL;DR: When the same blood sample was run twice, six widely used epigenetic clocks disagreed with themselves by as much as 9 years (Higgins-Chen, Nature…
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How to Slow Immune Aging With Spermidine: The Protocol a 2026 Trial Actually Tested
TL;DR: A 2026 double-blind trial in Aging Cell found that 6mg of spermidine daily for 13 weeks reduced immune cell senescence markers, enhanced autophagy in…
