Science-Based Biohacking for Longevity
Daily evidence-based insights helping you live stronger, longer, and sharper.
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Did a 4-Week Diet Reverse Biological Age? What the Sydney Trial Actually Measured
Read more: Did a 4-Week Diet Reverse Biological Age? What the Sydney Trial Actually MeasuredTL;DR: In a 2026 University of Sydney trial, 104 adults aged 65 to 75 ate one of four fully provided diets for 4 weeks. Three of the diets moved a biomarker score called KDM biological age by roughly 3 to 4 points compared with a diet close to what people already ate, but only some…
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Does Hyperbaric Oxygen Therapy Reverse Aging? Myth vs. Data
Read more: Does Hyperbaric Oxygen Therapy Reverse Aging? Myth vs. DataTL;DR: No. In the randomized trials we identified, HBOT has not been shown to reverse biological age measured with validated epigenetic clocks. The “age reversal” claim rests on an uncontrolled telomere analysis in 25 older adults, while two randomized trials from the same Israeli center found functional gains (cognition, VO2max), which are not the same…
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How to Lower Biological Age: What Randomized Trials Actually Show
Read more: How to Lower Biological Age: What Randomized Trials Actually ShowTL;DR: Only a handful of randomized trials have tested whether a lifestyle or supplement intervention changes DNA methylation measures of biological age. Caloric restriction (CALERIE), omega-3 (DO-HEALTH) and an 8-week diet-and-lifestyle program (Fitzgerald pilot) each moved at least one clock, but the effects were small, differed from clock to clock, and none of these trials…
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Low-Dose Lithium for Brain Aging: The Evidence and What an Evidence-Based Protocol Looks Like
Read more: Low-Dose Lithium for Brain Aging: The Evidence and What an Evidence-Based Protocol Looks LikeTL;DR: Texas counties with higher lithium in drinking water showed significantly lower Alzheimer’s mortality. A 2025 study found lithium levels are lower in Alzheimer’s brains. Two-year controlled trials show lithium stabilizes cognition where placebo shows decline. Lithium orotate, not lithium carbonate, appears to reach the brain at low doses. The protocol below is based on…
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Rapamycin for Longevity: What the PEARL Trial Actually Found After 48 Weeks in Humans
Read more: Rapamycin for Longevity: What the PEARL Trial Actually Found After 48 Weeks in Humans114 adults, 48 weeks, placebo-controlled: the first rigorous human rapamycin longevity trial found a 5% lean mass gain in women and a favorable safety profile.
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Antioxidant Supplements Slow Aging: What the Science Actually Shows
Read more: Antioxidant Supplements Slow Aging: What the Science Actually ShowsThe largest human trials — 296,707 participants across 78 RCTs — show antioxidant supplements increase mortality, not reduce it. Here is what the data actually says, and what works instead.
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Alpha-Ketoglutarate (AKG) for Aging: What the Research Actually Shows
Read more: Alpha-Ketoglutarate (AKG) for Aging: What the Research Actually ShowsTL;DR: Alpha-ketoglutarate (AKG) is a metabolite in the Krebs cycle that declines by roughly 50% between ages 40 and 70. A 2020 Cell Metabolism study found calcium AKG extended median lifespan in mice by up to 12% and compressed the period of decline at end of life. A 2021 human study in 42 adults reported…
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Berberine vs. Metformin for Longevity: What the Evidence Actually Shows
Read more: Berberine vs. Metformin for Longevity: What the Evidence Actually ShowsTL;DR: Berberine and metformin share a core mechanism — both activate AMPK — and both lower fasting glucose comparably in head-to-head trials. Metformin brings 70 years of human safety data, an epidemiological signal for reduced all-cause mortality, and the ongoing TAME trial specifically testing it for longevity. Berberine brings comparable metabolic effects without a prescription,…
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Biological Age Tests Compared: Noise Alone Can Move Your Result 9 Years
Read more: Biological Age Tests Compared: Noise Alone Can Move Your Result 9 YearsTL;DR: When the same blood sample was run twice, six widely used epigenetic clocks disagreed with themselves by as much as 9 years (Higgins-Chen, Nature Aging, 2022). That one finding reorders the entire consumer market, because a test that cannot reproduce its own answer cannot tell you whether anything you did worked. Methylation-based pace-of-aging measures…
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How to Slow Immune Aging With Spermidine: The Protocol a 2026 Trial Actually Tested
Read more: How to Slow Immune Aging With Spermidine: The Protocol a 2026 Trial Actually TestedTL;DR: A 2026 double-blind trial in Aging Cell found that 6mg of spermidine daily for 13 weeks reduced immune cell senescence markers, enhanced autophagy in B cells, and improved vaccine responses in older adults who had previously not responded to immunization. The effects persisted 24 weeks after supplementation ended. The protocol involves three steps: dietary…